-449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis

Ranji Hayashi, Tomomitsu Tahara, Tsukasa Yamaaki, Takashi Saito, Kazuhiro Matsunaga, Nobuhiko Hayashi, Atsushi Fukumura, Kazuaki Ozaki, Masakatsu Nakamura, Hisakazu Shiroeda, Mikihiro Tsutsumi, Tomoyuki Shibata, Tomiyasu Arisawa

研究成果: Article

3 引用 (Scopus)

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AIM: To clarify the association between a polymorphism -449 C>G (rs72696119) in 5'-UTR of NFKB1 with ulcerative colitis (UC). METHODS: The studied population comprised 639 subjects, including patients with UC (UC cases, n = 174) and subjects without UC (controls, n = 465). We employed polymerase chain reaction-single strand conformation polymorphism to detect the gene polymorphism. RESULTS: The rs72696119 G allele frequencies in controls and UC cases were 33.4% and 38.5%, respectively (P = 0.10). Genotype frequency of the GG homozygote in UC cases was significantly higher than that in controls (P = 0.017), and the GG homozygote was significantly associated with susceptibility to UC [odds ratio (OR), 1.88; 95%CI, 1.13-3.14]. In male subjects, the GG homozygote was associated with an increased risk for UC (OR, 3.10; 95%CI, 1.47-6.54; P = 0.0053), whereas this association was not found in female subjects. In addition, the GG homozygote was significantly associated with the risk of non-continuous disease (OR, 2.06; 95%CI, 1.12-3.79; P = 0.029), not having total colitis (OR, 2.40; 95%CI, 1.09-3.80, P = 0.040), disease which developed before 20 years of age (OR, 2.80; 95%CI, 1.07-7.32, P = 0.041), no hospitalization (OR, 2.28; 95%CI, 1.29-4.05; P = 0.0090) and with a maximum of 8 or less on the UCDAI score (OR, 2.45; 95%CI, 1.23-4.93; P = 0.022). CONCLUSION: Our results provide evidence that NFKB1 polymorphism rs72696119 was significantly associated with the development of UC. This polymorphism influences the susceptibility to and pathophysiological features of UC.

元の言語English
ページ(範囲)6981-6986
ページ数6
ジャーナルWorld Journal of Gastroenterology
18
発行部数47
DOI
出版物ステータスPublished - 01-12-2012

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All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Hayashi, R., Tahara, T., Yamaaki, T., Saito, T., Matsunaga, K., Hayashi, N., Fukumura, A., Ozaki, K., Nakamura, M., Shiroeda, H., Tsutsumi, M., Shibata, T., & Arisawa, T. (2012). -449 C>G polymorphism of NFKB1 gene, coding nuclear factor-kappa-B, is associated with the susceptibility to ulcerative colitis. World Journal of Gastroenterology, 18(47), 6981-6986. https://doi.org/10.3748/wjg.v18.i47.6981