TY - JOUR
T1 - A case of autochthonous hepatitis e infected with subgenotype 4A hepatitis E virus endemic in China without overseas travel
AU - Nakagawa, Naoki
AU - Nakano, Tatsunori
AU - Sak-Aguchi, Ryohei
AU - Fukui, Toshitaka
AU - Higuchi, Kunihiro
AU - Nakashima, Shigehito
AU - Takaji, Satoshi
AU - Miyoshi, Miho
AU - Nagashima, Shigeo
AU - Takahashi, Masaharu
AU - Watanabe, Shozo
AU - Takei, Yoshiyuki
AU - Okamoto, Hiroaki
N1 - Publisher Copyright:
© 2020 The Japan Society of Hepatology.
PY - 2020
Y1 - 2020
N2 - We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.
AB - We experienced a case of autochthonous hepatitis E by hepatitis E virus (HEV) genotype 4. The phyloge-netic tree analysis indicated that the HEV isolate ob-tained from the patient was segregated into the HEV subgenotype 4a (HEV-4a) cluster. The patient had no history of travel abroad, e.g., to China, where HEV-4a strains are endemic. The source and the route of the HEV-4a infection were unknown. Strains of HEV-4a may be indigenous to Japan despite remaining unde-tected to date, either in swine or wild animals. Addi-tional HEV subgenotypes circulating in swine and wild animals in Japan require investigation to reveal the characteristics of HEV-4a infection in autochthonous cases in Japan.
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U2 - 10.2957/kanzo.61.270
DO - 10.2957/kanzo.61.270
M3 - Article
AN - SCOPUS:85084608276
SN - 0451-4203
VL - 61
SP - 270
EP - 272
JO - Kanzo/Acta Hepatologica Japonica
JF - Kanzo/Acta Hepatologica Japonica
IS - 5
ER -
