A case of delayed emergence after propofol anesthesia: Genetic analysis

Hiroshi Yonekura, Norie Murayama, Hiroshi Yamazaki, Kazuya Sobue

研究成果: Chapter

5 被引用数 (Scopus)

抄録

This case report describes a 71-year-old woman who experienced unusual delayed emergence from propofol, which lasted for 3 hours and resulted in admission to the intensive care unit. Because genetic variations of propofol-metabolizing enzymes are proposed to be causal factors, we explored genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) and uridine 5'-diphospho-glucuronosyltransferase 1A9 (UGT1A9). Suggested high-risk factors (advanced age, CYP2B6 516 G/T, and UGT1A9 1399 C/C) were observed in this case of delayed propofol metabolism. Therefore, genetic variants involved in propofol metabolism should be considered in unexplained delayed emergence.

本文言語English
ホスト出版物のタイトル100 Selected Case Reports from Anesthesia and Analgesia
出版社Wolters Kluwer Health
ISBN(電子版)9781975115333
ISBN(印刷版)9781975115326
DOI
出版ステータスPublished - 01-01-2018
外部発表はい

All Science Journal Classification (ASJC) codes

  • 医学(全般)

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