A case of fulminant type 1 diabetes mellitus acquired in the 7th week of pregnancy

Nobuki Hayakawa, Masaki Makino, Hiroaki Kakizawa, Shigeo Imamura, Keiko Yamamoto, Kentaro Fujiwara, Yoshikuni Sawai, Naohisa Oda, Mitsuyasu Itoh

研究成果: Article査読

2 被引用数 (Scopus)

抄録

A-33-year-old woman who suddenly developed excessive thirst on March 31, 2001, and was admitted on April 2, 2001, due to an impending abortion lost consciousness after the abortion and was transferred to our hospital. Her blood glucose was 789 mg/dl with severe metabolic acidosis, pH 7.006, and positive serum and urinary ketone bodies, consistent with diabetic ketoacidosis. Her HbA1C was close to normal (6.1%), while urinary C-peptide was very low (1.2 μg/day). Serum concentrations of amylase, lipase, and elastase 1 were elevated. The results of a glucagon loading test showed impaired insulin secretion. Diabetes-related autoantibodies including anti-GAD-antibody, anti-IA-2-antibody, and ICA were all negative. Her HLA type was A2, A 24 (9), B 61 (40), B 51 (5), DR 2, DR 8, DQ 1, and DQ 4. The onset of type 1 diabetes during pregnancy has mostly been reported during the 2nd and 3rd trimesters and is rare in early pregnancy. Fulminant type 1 diabetes has been proposed characterized by near-normal HbA1C despite diabetic ketoacidosis and rapid loss of insulin secretion. Here, we report the case of a pregnant woman who developed typical fulminant type 1 diabetes as early as 7 weeks into gestation.

本文言語English
ページ(範囲)881-887
ページ数7
ジャーナルJournal of the Japan Diabetes Society
45
12
出版ステータスPublished - 01-12-2002

All Science Journal Classification (ASJC) codes

  • 内科学
  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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