A case of gastric cancer with peritoneal dissemination who achieved long survival from control of ascites for over 2 years by successive treatments with S-1 in combination with docetaxel as first-line followed by irinotecan in combination with cisplatin as second-line

Tomoyoshi Ohno, Noriyuki Horiguchi, Koki Asukai, Aki Miura, Hiroki Koguchi, Shuya Shimizu, Seijiro Matsunaga, Shozo Togawa, Izumi Hasegawa, Kenji Sakakibara

研究成果: Article査読

抄録

The patient was a 66-year-old male, admitted and diagnosed as having advanced gastric cancer with peritoneal dissemination, leading to ascites and obstructive jaundice. After reducing the degree of obstructive jaundice, combination chemotherapy of S-1 80 mg/m2/day (2 weeks administration and 1 week rest) and docetaxel (TXT) 40 mg/m2 (day 1) was administered from Februar, 2008. After 3 courses of this regimen, CT revealed no evidence of ascites, and this chemotherapy was successively continued on an outpatient basis until June, 2009. After the relapse of ascites from July, 2009, combination chemotherapy of irinotecan (CPT-11) 60 mg/m2 and cisplatin (CDDP) 30 mg/m2 biweekly was performed as second-line chemotherapy, and the ascites disappeared again after around 2 courses of this regimen. This chemotherapy was continued on an outpatient basis until February, 2010. No major adverse reaction to either chemotherapy was observed. This case suggests that these chemotherapies, such as the combination chemotherapy of S-1 plus TXT as a first-line treatment and CPT-11 plus CDDP as the following second-line treatment, can be administered to an outpatient, can keep good patient's QOL and can be one of the effective chemotherapy options for advanced gastric cancer with peritoneal dissemination.

本文言語English
ページ(範囲)1123-1126
ページ数4
ジャーナルJapanese Journal of Cancer and Chemotherapy
39
7
出版ステータスPublished - 07-2012
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

フィンガープリント

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