A case of intractable hepatic encephalopathy successfully treated by oral administration of vancomycin hydrochloride, with subsequent improvement of hepatic function reserve enabling transcatheter arterial chemoembolization against hepatocellular carcinoma

Teiji Kuzuya, Kinichi Takeda, Setsuo Utsunomiya, Masahiro Taga, Noboru Kawata, Takashi Ikeda, Norihiro Imai, Yoshitaka Mizutani, Ken Hirose, Tetsuya Ishikawa

研究成果: Article査読

抄録

We report a case of an 80-year-old male who suffered from intractable hepatic encephalopathy and hepatocellular carcinoma (HCC), associated with hepatitis type C-related liver cirrhosis. He was unable to receive HCC treatment due to the deterioration of his liver. His hepatic encephalopathy was resistant to oral administration of laxatives, lactulose, and kanamycin sulfate, etc. His blood ammonia concentration averaged about 130 μg/dL, and often exceeded 200 μg/dL (normal range: <80 μg/dL). Later, an oral administration of vancomycin hydrochloride, 0.5 g once every 3 days, was initiated. Soon after ward, his blood ammonia concentration declined to the normal range (about 50 μg/dL), and the clinical symptoms of hepatic encephalopathy showed a remarkable improvement. By the continuation of vancomycin administration, the normalization of his state of consciousness was achieved, improving his quality of life, and his activities of daily living. Three months after beginning treatment, he was able to receive transcatheter arterial chemoembolization for the treatment of HCC, because his liver function reserve improved (Child-Pugh score decreased from 10 to 7).

本文言語English
ページ(範囲)995-997
ページ数3
ジャーナルJapanese Journal of Cancer and Chemotherapy
38
6
出版ステータスPublished - 06-2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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