A case of lymphoepithelioma-like carcinoma of the skin

A 69-year-old man was presented to our hospital for the complaint of a facial skin nodule that had been present for approximately six months. On his right temple, a highly mobile 10 × 10 × 2mm facial skin nodule was recognized. We suspected that the nodule was a skin appendage tumor and treated the patient by local excision under local anesthesia. Histopathological examination revealed that the tumor showed no continuity with the epidermis, but rather formed lobulated cell nests that propagated into the dermis. The tumor cells had cytological atypia, and immunohistochemistry showed that the tumor cells were positive for cytokeratin 7, CEA, and EMA stain, while negative for S-100 and cytokeratin 20. No atypical lymphocyte infiltration was seen around the tumor nest. Head CT and nasopharynx fiberscopy showed no abnormalities. The patient was diagnosed with lymphoepithelioma-like carcinoma of the skin.