A case of neural cell adhesion molecule-positive peripheral T-cell lymphoma associated with human T-cell lymphotrophic virus type 1 showing an unusual involvement of the gastrointestinal tract during the course of the disease

Kayoko Hayashi, Shigeo Nakamura, Takashi Koshikawa, Kuniyoshi Kitoh, Koichi Koike, Hirokazu Komatsu, Makoto Kuroda, Masao Kasahara, Ryuzo Ueda, Taizan Suchi

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We report a case of neural cell adhesion molecule (NCAM)-positive peripheral T-cell lymphoma (PTCL), pleomorphic, medium and large cell type according to the updated Kiel classification, which was associated with human T-cell lymphotrophic virus type 1 (HTLV-1). The patient showed an unusual involvement of the gastrointestinal tract forming a bulky mass during the course of his disease, and a relatively indolent clinical course for 53 months until death. Phenotypic analysis showed CD2+, CD3-, CD4+, CD5+, CD7+, CD8-, CD16-, CD56+, and CD57- phenotype. Human T-cell lymphotrophic virus type 1 antibody was detected by the enzyme-linked immunosorbent assay. The proviral integration of HTLV-1 and the monoclonal rearrangements of T-cell receptor beta and gamma genes also were confirmed in DNA extract from fresh material. This fact calls attention to NCAM as one of the potential factors playing a role in the localization and behavior of lymphomas even within the category of PTCL associated with HTLV-1, ie, adult T-cell leukemia/lymphoma (ATLL).

本文言語English
ページ(範囲)1251-1253
ページ数3
ジャーナルHuman Pathology
25
11
DOI
出版ステータスPublished - 11-1994

All Science Journal Classification (ASJC) codes

  • 病理学および法医学

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