A case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis after a single infusion of tocilizumab

Fumiaki Sugiura, Toshihisa Kojima, Takeshi Oguchi, Shirou Urata, Yukio Yuzawa, Akihiro Sakakibara, Hiroki Hayashi, Norihiro Nishimoto, Naoki Ishiguro

研究成果: Article査読

12 被引用数 (Scopus)

抄録

We report a case of peripheral neuropathy and skin ulcer in a patient with rheumatoid arthritis (RA) who received tocilizumab. A 65-year-old woman with a 20-year history of RA participated in a tocilizumab clinical trial. She received a single dose of 8 mg/kg tocilizumab intravenously. The following day the patient started to experience numbness and purpura in all four extremities. The purpura of her left lower limb became necrotic, and a skin ulcer appeared 3 weeks later. Steroid-pulse treatment was initiated 12 weeks after tocilizumab administration, with the result that the numbness improved, and the skin ulcers showed complete epithelialization.

本文言語English
ページ(範囲)199-203
ページ数5
ジャーナルModern Rheumatology
19
2
DOI
出版ステータスPublished - 2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • リウマチ学

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