A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses

Ryoko Saito, Fumiyoshi Fujishima, Yasuhiro Nakamura, Yasushi Hoshikawa, Junya Tominaga, Shinji Taniuchi, Atsuko Kasajima, Mika Watanabe, Yoshinori Okada, Hironobu Sasano

研究成果: Article

1 引用 (Scopus)

抄録

Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.

元の言語English
ページ(範囲)224-229
ページ数6
ジャーナルPathology International
66
発行部数4
DOI
出版物ステータスPublished - 01-04-2016

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Osteoclasts
Giant Cells
Macrophage Colony-Stimulating Factor
Neoplasms
Adenocarcinoma of lung
Mucinous Adenocarcinoma
Lung
Mutation
Cell Differentiation
Pancreas
Adenocarcinoma
Epithelium

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

これを引用

Saito, Ryoko ; Fujishima, Fumiyoshi ; Nakamura, Yasuhiro ; Hoshikawa, Yasushi ; Tominaga, Junya ; Taniuchi, Shinji ; Kasajima, Atsuko ; Watanabe, Mika ; Okada, Yoshinori ; Sasano, Hironobu. / A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells : Its evaluation by immunohistochemical and genetic analyses. :: Pathology International. 2016 ; 巻 66, 番号 4. pp. 224-229.
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abstract = "Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.",
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Saito, R, Fujishima, F, Nakamura, Y, Hoshikawa, Y, Tominaga, J, Taniuchi, S, Kasajima, A, Watanabe, M, Okada, Y & Sasano, H 2016, 'A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells: Its evaluation by immunohistochemical and genetic analyses', Pathology International, 巻. 66, 番号 4, pp. 224-229. https://doi.org/10.1111/pin.12395

A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells : Its evaluation by immunohistochemical and genetic analyses. / Saito, Ryoko; Fujishima, Fumiyoshi; Nakamura, Yasuhiro; Hoshikawa, Yasushi; Tominaga, Junya; Taniuchi, Shinji; Kasajima, Atsuko; Watanabe, Mika; Okada, Yoshinori; Sasano, Hironobu.

:: Pathology International, 巻 66, 番号 4, 01.04.2016, p. 224-229.

研究成果: Article

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T1 - A case of pulmonary adenocarcinoma harboring osteoclast-like giant cells

T2 - Its evaluation by immunohistochemical and genetic analyses

AU - Saito, Ryoko

AU - Fujishima, Fumiyoshi

AU - Nakamura, Yasuhiro

AU - Hoshikawa, Yasushi

AU - Tominaga, Junya

AU - Taniuchi, Shinji

AU - Kasajima, Atsuko

AU - Watanabe, Mika

AU - Okada, Yoshinori

AU - Sasano, Hironobu

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.

AB - Tumors harboring osteoclast-like giant cells (OGCs) at extraosseous site are extremely rare. These rare tumors have been detected most frequently in the pancreas and few pulmonary tumors harboring OGCs have been previously reported. In addition, the genetic profiles of these tumors have remained virtually unknown. Therefore, we report a case of pulmonary adenocarcinoma harboring OGCs in which k-ras mutation and immunohistochemical study of proteins associated with OGCs were examined. The case was a 70-year-old man, who demonstrated a pulmonary mass associated with unusual radiological features. Histopathologically, three different cell types, mucinous adenocarcinoma cell, OGC and mononuclear cell were detected. OGCs were immunohistochemically negative for epithelial markers and positive for histiocytic markers but mononuclear cells were immunopositive for epithelial markers. In addition, both mononuclear and adenocarcinoma cells had the same k-ras mutation profiles and mononuclear cells were immunohistochemically positive for macrophage colony-stimulating factor (M-CSF), one of the factors associated with OGC differentiation. Therefore, mononuclear cells were considered to be derived from neoplastic epithelium and OGCs could represent non-neoplastic cells. In addition, M-CSF locally produced could promote the differentiation of OGCs.

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