抄録
A 59-year old male patient had been operated on for sigmoid colon cancer in July, 1990. Operative findings were P 0, H 0, S 1, N (-), Stage I, and histological findings were ss, ly 2, v O, n (-). In July 1994, the CEA level elevated, and he was diagnosed as having para-aortic LN swelling and stenosis of anastomosis of colon. He was admitted for treatment of recurrent colon cancer. Initially, he was treated with continuous injection of 5-FU, low- dose CDDP and Leucovorin. His CEA level decreased and para-aortic LN diminished in size. But, in December 1995, the CEA level and para-aortic LN relapsed. 5-FU, CDDP and Leucovorin were administered, but the CEA level became more and more elevated. This regimen was not considered responsible for drug resistance. CPT-11 was administered at 60 mg/week 6 times, and 80 mg/week 3 times. The side effects disappeared, LN sightly diminished in size, and the CEA level decreased. Judging by the anticancer effect without severe side effect, we found CPT-11 a useful drug for second-line chemotherapy.
| 元の言語 | English |
|---|---|
| ページ（範囲） | 1315-1319 |
| ページ数 | 5 |
| ジャーナル | Japanese Journal of Cancer and Chemotherapy |
| 巻 | 24 |
| 発行部数 | 10 |
| 出版物ステータス | Published - 24-09-1997 |
| 外部発表 | Yes |
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All Science Journal Classification (ASJC) codes
- Cancer Research
- Pharmacology
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A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy. / Kawabe, S.; Takiuchi, H.; Hirata, I.; Takao, Y.; Nakagawa, K.; Egashira, Y.; Nakagawa, Y.; Katsu, K.
：: Japanese Journal of Cancer and Chemotherapy, 巻 24, 番号 10, 24.09.1997, p. 1315-1319.研究成果: Article
TY - JOUR
T1 - A case of recurrent advanced colon cancer treated with CPT-11 for second-line chemotherapy
AU - Kawabe, S.
AU - Takiuchi, H.
AU - Hirata, I.
AU - Takao, Y.
AU - Nakagawa, K.
AU - Egashira, Y.
AU - Nakagawa, Y.
AU - Katsu, K.
PY - 1997/9/24
Y1 - 1997/9/24
N2 - A 59-year old male patient had been operated on for sigmoid colon cancer in July, 1990. Operative findings were P 0, H 0, S 1, N (-), Stage I, and histological findings were ss, ly 2, v O, n (-). In July 1994, the CEA level elevated, and he was diagnosed as having para-aortic LN swelling and stenosis of anastomosis of colon. He was admitted for treatment of recurrent colon cancer. Initially, he was treated with continuous injection of 5-FU, low- dose CDDP and Leucovorin. His CEA level decreased and para-aortic LN diminished in size. But, in December 1995, the CEA level and para-aortic LN relapsed. 5-FU, CDDP and Leucovorin were administered, but the CEA level became more and more elevated. This regimen was not considered responsible for drug resistance. CPT-11 was administered at 60 mg/week 6 times, and 80 mg/week 3 times. The side effects disappeared, LN sightly diminished in size, and the CEA level decreased. Judging by the anticancer effect without severe side effect, we found CPT-11 a useful drug for second-line chemotherapy.
AB - A 59-year old male patient had been operated on for sigmoid colon cancer in July, 1990. Operative findings were P 0, H 0, S 1, N (-), Stage I, and histological findings were ss, ly 2, v O, n (-). In July 1994, the CEA level elevated, and he was diagnosed as having para-aortic LN swelling and stenosis of anastomosis of colon. He was admitted for treatment of recurrent colon cancer. Initially, he was treated with continuous injection of 5-FU, low- dose CDDP and Leucovorin. His CEA level decreased and para-aortic LN diminished in size. But, in December 1995, the CEA level and para-aortic LN relapsed. 5-FU, CDDP and Leucovorin were administered, but the CEA level became more and more elevated. This regimen was not considered responsible for drug resistance. CPT-11 was administered at 60 mg/week 6 times, and 80 mg/week 3 times. The side effects disappeared, LN sightly diminished in size, and the CEA level decreased. Judging by the anticancer effect without severe side effect, we found CPT-11 a useful drug for second-line chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=0030959794&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030959794&partnerID=8YFLogxK
M3 - Article
C2 - 9279352
AN - SCOPUS:0030959794
VL - 24
SP - 1315
EP - 1319
JO - Japanese Journal of Cancer and Chemotherapy
JF - Japanese Journal of Cancer and Chemotherapy
SN - 0385-0684
IS - 10
ER -