A comparative study: visual rating scores and the voxel-based specific regional analysis system for Alzheimer's disease on magnetic resonance imaging among subjects with Alzheimer's disease, mild cognitive impairment, and normal cognition

Fangzhou Li, Hajime Takechi, Ryuji Saito, Takashi Ayaki, Atsuko Kokuryu, Akira Kuzuya, Ryosuke Takahashi

研究成果: Article

抜粋

Aim: Hippocampal atrophy shown on magnetic resonance imaging can differentiate Alzheimer's disease (AD) patients from subjects with normal cognition (NC). Simplified automated methods that use volumetric analysis, such as as the voxel-based specific regional analysis system for AD, have become widely used in Japan. However, the diagnostic value of the voxel-based specific regional analysis system compared with visual rating scores for clinical diagnosis is unclear. Methods: Study participants consisted of 37 AD patients, 29 mild cognitive impairment (MCI) patients, and 21 NC subjects. All participants underwent neuropsychological testing and magnetic resonance imaging. The imaging was scored visually for regional brain atrophy by two raters based on a newly developed visual rating score. The voxel-based specific regional analysis system for AD scores were calculated with the analysis system's advanced software. We analyzed whether these scores aid in discriminating among AD, MCI, and NC. Results: The AD group had significantly different visual rating scores, regional analysis scores, and all neuropsychological test scores than the NC group. The AD group had significantly different visual rating scores than the MCI group, and a significant difference was observed between the MCI and NC groups on regional analysis scores. Both the visual rating and regional analysis scores showed equivalent correlations with the neuropsychological test scores. Conclusions: Both the visual rating and regional analysis scores are clinically useful tools for differentiating among AD, MCI, and NC.

元の言語English
ページ(範囲)95-104
ページ数10
ジャーナルPsychogeriatrics
19
発行部数2
DOI
出版物ステータスPublished - 03-2019

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

これを引用