A crucial effect of ligand clustering on the inhibition of binding by L-selectin in intercellular adhesion

Tomoaki Yoshida, Noriko Toyama-Sorimachi, Masayuki Miyasaka, Yuan C. Lee

研究成果: Article査読

15 被引用数 (Scopus)

抄録

Glucan sulfates were found to be potent ligands for L-selectin by a quantitative liquid phase analysis system (Yoshida, T. et al., Eur. J. Biochem., in press). The affinity of glucan sulfates to L-selectin-IgG chimera was dependent on the sizes of the glucan sulfates as well as on the inter-glucose linkages. In the current report, these glucan sulfates are shown to inhibit the interaction of an endothelial cell line with lymphocytes. The effect of ligand size appears to be more remarkable in the cell-cell binding than in the liquid phase analysis. The affinity of amylose sulfate continues to increase, as their size increases even beyond 12 kDa, at which its affinity reached a plateaux in the liquid phase analysis.

本文言語English
ページ(範囲)969-974
ページ数6
ジャーナルBiochemical and Biophysical Research Communications
204
2
DOI
出版ステータスPublished - 28-10-1994
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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