A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia

Hideaki Wakita, Hidekazu Tomimoto, Ichiro Akiguchi, Jin Xi Lin, Katsuichi Miyamoto, Nobuyuki Oka

研究成果: Article

44 引用 (Scopus)

抄録

The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.

元の言語English
ページ(範囲)1461-1465
ページ数5
ジャーナルNeuroReport
10
発行部数7
DOI
出版物ステータスPublished - 14-05-1999

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nimesulide
Cyclooxygenase 2 Inhibitors
Brain Ischemia
Microglia
Cerebrovascular Disorders
Histocompatibility Antigens
Common Carotid Artery
Major Histocompatibility Complex
Ligation
Serum
White Matter

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Wakita, Hideaki ; Tomimoto, Hidekazu ; Akiguchi, Ichiro ; Lin, Jin Xi ; Miyamoto, Katsuichi ; Oka, Nobuyuki. / A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. :: NeuroReport. 1999 ; 巻 10, 番号 7. pp. 1461-1465.
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abstract = "The effects of nimesulide, a cyclooxygenase-2 inhibitor, were examined during chronic cerebral hypoperfusion. After bilateral ligation of the common carotid arteries in 30 rats, 21 received dosages of 2 or 5mg/kg nimesulide daily and nine received vehicle daily for 14 days. The serum was then analyzed biochemically, and pathological changes were estimated in the white matter by the emergence of major histocompatibility complex (MHC) antigen- immunoreactive activated microglia and white matter lesions. In the vehicle- treated animals, activated microglia and white matter lesions were observed. Following treatment with either 2 or 5mg/kg nimesulide, the magnitude of these changes was reduced (p < 0.001) without significant side effects. These results indicate a potential use for cyclooxygenase-2 inhibitors in cerebrovascular disease.",
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Wakita, H, Tomimoto, H, Akiguchi, I, Lin, JX, Miyamoto, K & Oka, N 1999, 'A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia', NeuroReport, 巻. 10, 番号 7, pp. 1461-1465. https://doi.org/10.1097/00001756-199905140-00013

A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia. / Wakita, Hideaki; Tomimoto, Hidekazu; Akiguchi, Ichiro; Lin, Jin Xi; Miyamoto, Katsuichi; Oka, Nobuyuki.

:: NeuroReport, 巻 10, 番号 7, 14.05.1999, p. 1461-1465.

研究成果: Article

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