A cyclosporin A/maltosyl-α-cyclosdextrin complex for inhalation therapy of asthma

Hiroaki Fukaya, A. Iimura, K. Hoshiko, T. Fuyumuro, S. Noji, T. Nabeshima

研究成果: Article査読

19 被引用数 (Scopus)

抄録

The inhalation of cyclosporin (Cs)A to the lung is limited by its hydrophobic properties. In order to improve the poor solubility of CsA, cyclodextrin (CD) was evaluated for its suitability for dry powder inhaler formation, and the benefit of an inhaled CsA/CD complex in vivo was demonstrated. The solubilising effect of CDs on CsA was measured by high-performance liquid chromatography. Ciliostatic activity and haemolysis were determined to assess some safety profiles of CDs. The efficacy of an inhaled CsA/CD complex was evaluated by eosinophil infiltration into the bronchoalveolar lavage fluid in actively sensitised mice. CDs markedly improved the poor solubility of CsA. The ciliostatic and haemolytic activities of maltosyl-α-CD were the weakest of all the tested CDs. CsA inhaled alone showed inhibitory effects on allergen-induced eosinophilia. Inhalation of the complex of CsA with maltosyl-α-CD, where the dose of CsA was approximately nine-times less than that of CsA inhaled alone, also inhibited eosinophil accumulation significantly, with a longer duration of action in comparison with the response to CsA alone. Thus the effective dose of cyclosporin A could be reduced by formation of a complex with maltosyl-α-cyclodextrin, and a wider therapeutic safety margin by inhalation of cyclosporin A as a complex with maltosyl-α-cyclodextrin could be expected.

本文言語English
ページ(範囲)213-219
ページ数7
ジャーナルEuropean Respiratory Journal
22
2
DOI
出版ステータスPublished - 01-08-2003

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

フィンガープリント 「A cyclosporin A/maltosyl-α-cyclosdextrin complex for inhalation therapy of asthma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル