TY - JOUR
T1 - A Dirofilaria immitis polyprotein up-regulates nitric oxide production
AU - Tezuka, Hiroyuki
AU - Imai, Shinjiro
AU - Tsukidate, Setsuko
AU - Fujita, Koichiro
PY - 2002/9
Y1 - 2002/9
N2 - We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages,. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40-/-, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.
AB - We investigated the effect of recombinant Dirofilaria immitis polyprotein (rDiAg) on nitric oxide (NO) production by peritoneal macrophages,. rDiAg induced NO production by macrophages from wild-type and lipopolysaccharide-hyporesponsive C3H/HeJ, but not CD40-/-, mice. These results suggest that CD40 is involved in rDiAg-driven NO production by murine macrophages.
UR - http://www.scopus.com/inward/record.url?scp=0036719673&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036719673&partnerID=8YFLogxK
U2 - 10.1128/IAI.70.9.5283-5286.2002
DO - 10.1128/IAI.70.9.5283-5286.2002
M3 - Article
C2 - 12183583
AN - SCOPUS:0036719673
SN - 0019-9567
VL - 70
SP - 5283
EP - 5286
JO - Infection and Immunity
JF - Infection and Immunity
IS - 9
ER -
