A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice

Tuya Wang, Takanori Onouchi, Nami O. Yamada, Shuji Matsuda, Takao Senda

研究成果: Article

2 引用 (Scopus)

抄録

The adenomatous polyposis coli (APC) is a multifunctional protein as well as a tumor suppressor. To determine the functions of the C-terminal domain of APC, we explored APC 1638T/1638T (APC1638T) mice that express a truncated APC lacking the C-terminal domain. The APC1638T mice were tumor free and exhibited growth retardation. In the present study, we compared small intestinal crypt-villus cells homeostasis in APC +/+ (WT) mice and APC1638T mice. The body weight of APC1638T mice was significantly smaller than that of WT mice at all ages. The length of small intestine of APC1638T mice was significantly shorter than that of WT mice. The crypt-villus axis was significantly elongated, and the number of intestinal epithelial cells also increased in APC1638T mice compared with those in WT mice. However, the number of intestinal epithelial cells per 100 µm of villi was not different between WT and APC1638T mice. Migration and proliferation of intestinal epithelial cells in APC1638T mice were faster than that in WT mice. The population of Goblet cells, Paneth cells, and enteroendocrine cells was significantly altered in APC1638T mice. These results indicate that C-terminal domain of APC has a role in the regulation of intestinal epithelium homeostasis.

元の言語English
ページ(範囲)94-102
ページ数9
ジャーナルMedical Molecular Morphology
50
発行部数2
DOI
出版物ステータスPublished - 01-06-2017

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Epithelial Cells
Adenomatous Polyposis Coli
Population
Homeostasis
Paneth Cells
Enteroendocrine Cells
Goblet Cells
Intestinal Mucosa
Small Intestine
Neoplasms
Body Weight

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology

これを引用

Wang, Tuya ; Onouchi, Takanori ; Yamada, Nami O. ; Matsuda, Shuji ; Senda, Takao. / A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice. :: Medical Molecular Morphology. 2017 ; 巻 50, 番号 2. pp. 94-102.
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A disturbance of intestinal epithelial cell population and kinetics in APC1638T mice. / Wang, Tuya; Onouchi, Takanori; Yamada, Nami O.; Matsuda, Shuji; Senda, Takao.

:: Medical Molecular Morphology, 巻 50, 番号 2, 01.06.2017, p. 94-102.

研究成果: Article

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