A gas governing mucosal immunity

Hiroyuki Tezuka, Toshiaki Ohteki

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.

本文言語English
ページ(範囲)8039-8040
ページ数2
ジャーナルVaccine
28
50
DOI
出版ステータスPublished - 23-11-2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子医療
  • 免疫学および微生物学(全般)
  • 獣医学(全般)
  • 公衆衛生学、環境および労働衛生
  • 感染症

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