抄録
Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.
| 本文言語 | 英語 |
|---|---|
| ページ（範囲） | 8039-8040 |
| ページ数 | 2 |
| ジャーナル | Vaccine |
| 巻 | 28 |
| 号 | 50 |
| DOI | |
| 出版ステータス | 出版済み - 23-11-2010 |
| 外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 分子医療
- 免疫学および微生物学一般
- 獣医学一般
- 公衆衛生学、環境および労働衛生
- 感染症
UN SDG
この成果は、次の持続可能な開発目標に貢献しています
