A gas governing mucosal immunity

Hiroyuki Tezuka; Toshiaki Ohteki

doi:10.1016/j.vaccine.2010.09.027

A gas governing mucosal immunity

Hiroyuki Tezuka
, Toshiaki Ohteki

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

抄録

Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.

本文言語	英語
ページ（範囲）	8039-8040
ページ数	2
ジャーナル	Vaccine
巻	28
号	50
DOI	https://doi.org/10.1016/j.vaccine.2010.09.027
出版ステータス	出版済み - 23-11-2010
外部発表	はい

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All Science Journal Classification (ASJC) codes

分子医療
免疫学および微生物学一般
獣医学一般
公衆衛生学、環境および労働衛生
感染症

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10.1016/j.vaccine.2010.09.027

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abstract = "Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.",

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AU - Ohteki, Toshiaki

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AB - Immunoglobulin A (IgA), the most abundant Ig isotype in the body under steady-state conditions, helps to protect the body from mucosally transmitted pathogens and to maintain the homeostasis of commensal bacteria at the mucosal surface. Although it is well known that IgA is predominantly produced in mucosa-associated lymphoid tissues (MALT), little is known about why IgA class switch recombination (CSR) occurs in these tissues. We recently showed that nitric oxide (NO) released by specialized dendritic cells (DCs) is essential for IgA CSR in the MALT.

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JF - Vaccine

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A gas governing mucosal immunity

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UN SDG

All Science Journal Classification (ASJC) codes

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