A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

Yoichiro Kamatani, Sukanya Wattanapokayakit, Hidenori Ochi, Takahisa Kawaguchi, Atsushi Takahashi, Naoya Hosono, Michiaki Kubo, Tatsuhiko Tsunoda, Naoyuki Kamatani, Hiromitsu Kumada, Aekkachai Puseenam, Thanyachai Sura, Yataro Daigo, Kazuaki Chayama, Wasun Chantratita, Yusuke Nakamura, Koichi Matsuda

研究成果: Article

369 引用 (Scopus)

抄録

Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals1. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. We validated these associations by genotyping two SNPs from the region in three additional Japanese and Thai cohorts consisting of 1,300 cases and 2,100 controls (combined P = 6.34 × 10-39 and 2.31 × 10 -38, OR = 0.57 and 0.56, respectively). Subsequent analyses revealed risk haplotypes (HLA-DPA1 0202-DPB1 0501 and HLA-DPA1 0202-DPB1 0301, OR = 1.45 and 2.31, respectively) and protective haplotypes (HLA-DPA1 0103-DPB1 0402 and HLA-DPA1 0103-DPB1 0401, OR = 0.52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.

元の言語English
ページ(範囲)591-595
ページ数5
ジャーナルNature Genetics
41
発行部数5
DOI
出版物ステータスPublished - 01-05-2009

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HLA-DP Antigens
Genome-Wide Association Study
Chronic Hepatitis B
Haplotypes
Single Nucleotide Polymorphism
Hepatitis B virus
Liver Cirrhosis
Communicable Diseases
Liver Diseases
Hepatocellular Carcinoma
HLA-DPA1 antigen
Infection

All Science Journal Classification (ASJC) codes

  • Genetics

これを引用

Kamatani, Y., Wattanapokayakit, S., Ochi, H., Kawaguchi, T., Takahashi, A., Hosono, N., ... Matsuda, K. (2009). A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics, 41(5), 591-595. https://doi.org/10.1038/ng.348
Kamatani, Yoichiro ; Wattanapokayakit, Sukanya ; Ochi, Hidenori ; Kawaguchi, Takahisa ; Takahashi, Atsushi ; Hosono, Naoya ; Kubo, Michiaki ; Tsunoda, Tatsuhiko ; Kamatani, Naoyuki ; Kumada, Hiromitsu ; Puseenam, Aekkachai ; Sura, Thanyachai ; Daigo, Yataro ; Chayama, Kazuaki ; Chantratita, Wasun ; Nakamura, Yusuke ; Matsuda, Koichi. / A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. :: Nature Genetics. 2009 ; 巻 41, 番号 5. pp. 591-595.
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abstract = "Chronic hepatitis B is a serious infectious liver disease that often progresses to liver cirrhosis and hepatocellular carcinoma; however, clinical outcomes after viral exposure vary enormously among individuals1. Through a two-stage genome-wide association study using 786 Japanese chronic hepatitis B cases and 2,201 controls, we identified a significant association of chronic hepatitis B with 11 SNPs in a region including HLA-DPA1 and HLA-DPB1. We validated these associations by genotyping two SNPs from the region in three additional Japanese and Thai cohorts consisting of 1,300 cases and 2,100 controls (combined P = 6.34 × 10-39 and 2.31 × 10 -38, OR = 0.57 and 0.56, respectively). Subsequent analyses revealed risk haplotypes (HLA-DPA1 0202-DPB1 0501 and HLA-DPA1 0202-DPB1 0301, OR = 1.45 and 2.31, respectively) and protective haplotypes (HLA-DPA1 0103-DPB1 0402 and HLA-DPA1 0103-DPB1 0401, OR = 0.52 and 0.57, respectively). Our findings show that genetic variants in the HLA-DP locus are strongly associated with risk of persistent infection with hepatitis B virus.",
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Kamatani, Y, Wattanapokayakit, S, Ochi, H, Kawaguchi, T, Takahashi, A, Hosono, N, Kubo, M, Tsunoda, T, Kamatani, N, Kumada, H, Puseenam, A, Sura, T, Daigo, Y, Chayama, K, Chantratita, W, Nakamura, Y & Matsuda, K 2009, 'A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians', Nature Genetics, 巻. 41, 番号 5, pp. 591-595. https://doi.org/10.1038/ng.348

A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. / Kamatani, Yoichiro; Wattanapokayakit, Sukanya; Ochi, Hidenori; Kawaguchi, Takahisa; Takahashi, Atsushi; Hosono, Naoya; Kubo, Michiaki; Tsunoda, Tatsuhiko; Kamatani, Naoyuki; Kumada, Hiromitsu; Puseenam, Aekkachai; Sura, Thanyachai; Daigo, Yataro; Chayama, Kazuaki; Chantratita, Wasun; Nakamura, Yusuke; Matsuda, Koichi.

:: Nature Genetics, 巻 41, 番号 5, 01.05.2009, p. 591-595.

研究成果: Article

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T1 - A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians

AU - Kamatani, Yoichiro

AU - Wattanapokayakit, Sukanya

AU - Ochi, Hidenori

AU - Kawaguchi, Takahisa

AU - Takahashi, Atsushi

AU - Hosono, Naoya

AU - Kubo, Michiaki

AU - Tsunoda, Tatsuhiko

AU - Kamatani, Naoyuki

AU - Kumada, Hiromitsu

AU - Puseenam, Aekkachai

AU - Sura, Thanyachai

AU - Daigo, Yataro

AU - Chayama, Kazuaki

AU - Chantratita, Wasun

AU - Nakamura, Yusuke

AU - Matsuda, Koichi

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Kamatani Y, Wattanapokayakit S, Ochi H, Kawaguchi T, Takahashi A, Hosono N その他. A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics. 2009 5 1;41(5):591-595. https://doi.org/10.1038/ng.348