TY - JOUR
T1 - A genome-wide association study of late-onset Alzheimer's disease in a Japanese population
AU - Hirano, Atsushi
AU - Ohara, Tomoyuki
AU - Takahashi, Atsushi
AU - Aoki, Masayuki
AU - Fuyuno, Yuta
AU - Ashikawa, Kyota
AU - Morihara, Takashi
AU - Takeda, Masatoshi
AU - Kamino, Kouzin
AU - Oshima, Etsuko
AU - Okahisa, Yuko
AU - Shibata, Nobuto
AU - Arai, Heii
AU - Akatsu, Hiroyasu
AU - Ikeda, Masashi
AU - Iwata, Nakao
AU - Ninomiya, Toshiharu
AU - Monji, Akira
AU - Kitazono, Takanari
AU - Kiyohara, Yutaka
AU - Kubo, Michiaki
AU - Kanba, Shigenobu
N1 - Publisher Copyright:
Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.
AB - Objective: Although a number of genome-wide association studies (GWASs) of late-onset Alzheimer's disease (LOAD) have been carried out, there have been little GWAS data on East Asian populations. Design: To discover the novel susceptibility loci of LOAD, we carried out a GWAS using 816 LOAD cases and 7992 controls with a replication analysis using an independent panel of 1011 LOAD cases and 7212 controls in a Japanese population. In addition, we carried out a stratified analysis by APOE-ε4 status to eliminate the established effect of APOE region. Results: Our data indicated that 18p11.32 (rs1992269, P =9.77× 10-7), CNTNAP2 (rs802571, P= 1.26×10-6), and 12q24.23 (rs11613092, P =6.85×10-6) were suggestive loci for susceptibility to LOAD. Conclusion: We identified three suggestive loci for susceptibility to LOAD in a Japanese population. Among these, rs802571, located at intron 1 of CNTNAP2, was considered to be a plausible candidate locus from a functional perspective.
UR - https://www.scopus.com/pages/publications/84942565964
UR - https://www.scopus.com/pages/publications/84942565964#tab=citedBy
U2 - 10.1097/YPG.0000000000000090
DO - 10.1097/YPG.0000000000000090
M3 - Article
C2 - 26049409
AN - SCOPUS:84942565964
SN - 0955-8829
VL - 25
SP - 139
EP - 146
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 4
ER -
SDG 3 すべての人に健康と福祉を