A glycine receptor antagonist, strychnine, blocked NMDA receptor activation in the neonatal mouse neocortex

Naohisa Miyakawa, Shigeo Uchino, Takayuki Yamashita, Hidetsugu Okada, Takeshi Nakamura, Shuichi Kaminogawa, Yusei Miyamoto, Tatsuhiro Hisatsune

研究成果: Article査読

7 被引用数 (Scopus)

抄録

The NMDA receptor (NMDAR) is a Ca2+-permeable cation channel that plays a critical role in neural network formation during brain development. Since it is blocked in a voltage-dependent manner by extracellular Mg2+, in order for the NMDA to be activated, the membrane must be strongly depolarized. Immature neurons in the developing neocortex can be depolarized by ligand-gated Cl- channels, such as the glycine receptor (GlyR) or GABAA receptor (GABAAR). We here assess the contribution of GlyRs to Ca2+ influx via NMDARs in neonatal mouse cortical neurons. The GlyR antagonist, strychnine, was more effective in suppressing post-synaptic Ca2+ influx than the GABAAR antagonist, picrotoxin, suggesting greater potentiation of NMDARs by GlyRs than by GABAARs. The GlyR, known to be endogenously activated at this stage, may play a critical role in neocortical development.

本文言語English
ページ(範囲)1667-1673
ページ数7
ジャーナルNeuroreport
13
13
DOI
出版ステータスPublished - 16-09-2002
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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