A library of mutated Maackia amurensis hemagglutinin distinguishes putative glycoforms of immunoglobulin A1 from IgA nephropathy patients

Keisuke Maenuma, Mijung Yim, Kunimitsu Komatsu, Mayumi Hoshino, Ayumi Tachiki-Fujioka, Kazuo Takahashi, Yoshiyuki Hiki, Nicolai Bovin, Tatsuro Irimura

研究成果: Article

10 引用 (Scopus)

抜粋

Ten genetically modified Maackia amurensis hemagglutinin (MAH) clones at the carbohydrate-recognition loop were found to bind glycophorin A and a mucin mimetic with NeuAcα2-3Galβ1-3GalNAcα (monosialyl-T antigen) in different relative intensity. Binding profiles of these lectins to human serum IgA1 from healthy individuals and from IgA nephropathy patients were subjected to the cluster analysis. Two large groups, one with only healthy individuals and another with all IgA nephropathy patients, were generated. The results strongly suggest that the library of genetically modified MAH is a useful tool for serum diagnosis of IgA nephropathy.

元の言語English
ページ(範囲)3617-3624
ページ数8
ジャーナルJournal of Proteome Research
8
発行部数7
DOI
出版物ステータスPublished - 06-07-2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Chemistry(all)

フィンガープリント A library of mutated Maackia amurensis hemagglutinin distinguishes putative glycoforms of immunoglobulin A1 from IgA nephropathy patients' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用