TY - JOUR
T1 - A nested case-control study of stomach cancer in relation to green tea consumption in Japan
AU - Hoshiyama, Y.
AU - Kawaguchi, T.
AU - Miura, Y.
AU - Mizoue, T.
AU - Tokui, N.
AU - Yatsuya, H.
AU - Sakata, K.
AU - Kondo, T.
AU - Kikuchi, S.
AU - Toyoshima, H.
AU - Hayakawa, N.
AU - Tamakoshi, A.
AU - Ohno, Y.
AU - Yoshimura, T.
N1 - Funding Information:
This study was part of the Japan Collaborative Cohort Study for Evaluation of Cancer Risk sponsored by the Ministry of Education, Science, Sports and Culture of Japan (the JACC Study), a nationwide multicentre collaborative study to prospectively evaluate various risk or protective factors for cancer mortality and incidence. Details of the study design were reported previously. Briefly, the cohort included 110 792 men and women (46 465 and 64327, respectively), aged 40–79 years at recruitment, who were enrolled from 1988 to 1990. Enrollment was based on the participants of a general health checkup periodically provided by the 45 municipalities involved. The informed consent procedures were approved by the Ethics Committee of Medical Care and Research, University of Occupational and Environmental Health, Kitakyushu, and the Ethical Board of the Nagoya University School of Medicine, Japan.
Funding Information:
We sincerely thank all the members of the local health centres and the participants from the cities, towns, and villages for their cooperation in this study. We also thank Ms Hiromi Hoshino for her assistance with this research project. The grant sponsor for this paper was the Ministry of Education, Science, Sports and Culture of Japan: 61010076, 62010074, 63010074, 1010068, 2151065, 3151064, 4151063, 5151069, 6279102, 11181101, and 12218237.
PY - 2004/1/12
Y1 - 2004/1/12
N2 - To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40-79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (Cl): 0.6-2.8), 1.0 (95% Cl: 0.5-1.9), 0.8 (95% Cl: 0.4-1.6), and 1.2 (95% Cl: 0.6-2.5), respectively (P for trend = 0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.
AB - To evaluate whether green tea consumption provides protection against stomach cancer, the relative risks (RRs) were calculated in the Japan Collaborative Study for Evaluation of Cancer Risk, sponsored by the Ministry of Health and Welfare (JACC Study). The study was based on 157 incident cases and 285 controls aged 40-79 years. Cox proportional hazards regression analysis was used to estimate the RRs for stomach cancer. It was found that green tea consumption had no protective effect against stomach cancer. After adjustment for age, smoking status, H. pylori infection, history of peptic ulcer, and family history of stomach cancer along with certain dietary elements, the risks associated with drinking one or two, three or four, five to nine, and 10 or more cups of green tea per day, relative to those of drinking less than one cup per day, were 1.3 (95% confidence interval (Cl): 0.6-2.8), 1.0 (95% Cl: 0.5-1.9), 0.8 (95% Cl: 0.4-1.6), and 1.2 (95% Cl: 0.6-2.5), respectively (P for trend = 0.899). We found no inverse association between green tea consumption and the risk of stomach cancer.
UR - https://www.scopus.com/pages/publications/10744229977
UR - https://www.scopus.com/pages/publications/10744229977#tab=citedBy
U2 - 10.1038/sj.bjc.6601512
DO - 10.1038/sj.bjc.6601512
M3 - Article
C2 - 14710220
AN - SCOPUS:10744229977
SN - 0007-0920
VL - 90
SP - 135
EP - 138
JO - British Journal of Cancer
JF - British Journal of Cancer
IS - 1
ER -
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