抄録
A new SHV-derived extended-spectrum β-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 30 μM, respectively. SHV-24 was found to have a D179G substitution in the Ω-loop of the enzyme.
本文言語 | 英語 |
---|---|
ページ(範囲) | 1725-1727 |
ページ数 | 3 |
ジャーナル | Antimicrobial agents and chemotherapy |
巻 | 44 |
号 | 6 |
DOI | |
出版ステータス | 出版済み - 2000 |
外部発表 | はい |
All Science Journal Classification (ASJC) codes
- 薬理学
- 薬理学(医学)
- 感染症