A New SHV-derived extended-spectrum β-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the Ω-loop

Hiroshi Kurokawa, Tetsuya Yagi, Naohiro Shibata, Keigo Shibayama, Kazunari Kamachi, Yoshichika Arakawa

研究成果: ジャーナルへの寄稿学術論文査読

27 被引用数 (Scopus)

抄録

A new SHV-derived extended-spectrum β-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 30 μM, respectively. SHV-24 was found to have a D179G substitution in the Ω-loop of the enzyme.

本文言語英語
ページ(範囲)1725-1727
ページ数3
ジャーナルAntimicrobial agents and chemotherapy
44
6
DOI
出版ステータス出版済み - 2000
外部発表はい

All Science Journal Classification (ASJC) codes

  • 薬理学
  • 薬理学(医学)
  • 感染症

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