A New SHV-derived extended-spectrum β-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the Ω-loop

Hiroshi Kurokawa; Tetsuya Yagi; Naohiro Shibata; Keigo Shibayama; Kazunari Kamachi; Yoshichika Arakawa

doi:10.1128/AAC.44.6.1725-1727.2000

A New SHV-derived extended-spectrum β-lactamase (SHV-24) that hydrolyzes ceftazidime through a single-amino-acid substitution (D179G) in the Ω-loop

Hiroshi Kurokawa
, Tetsuya Yagi
, Naohiro Shibata
, Keigo Shibayama
, Kazunari Kamachi
, Yoshichika Arakawa

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

32 被引用数 (Scopus)

抄録

A new SHV-derived extended-spectrum β-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 30 μM, respectively. SHV-24 was found to have a D179G substitution in the Ω-loop of the enzyme.

本文言語	英語
ページ（範囲）	1725-1727
ページ数	3
ジャーナル	Antimicrobial agents and chemotherapy
巻	44
号	6
DOI	https://doi.org/10.1128/AAC.44.6.1725-1727.2000
出版ステータス	出版済み - 2000
外部発表	はい

All Science Journal Classification (ASJC) codes

薬理学
薬理学（医学）
感染症

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

文献へのアクセス

10.1128/AAC.44.6.1725-1727.2000

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引用スタイル

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abstract = "A new SHV-derived extended-spectrum β-lactamase (SHV-24) conferring high-level resistance to ceftazidime but not cefotaxime and cefazolin was identified in Japan. This enzyme was encoded by a transferable 150-kb plasmid from an Escherichia coli clinical isolate. The pI and K(m) for CAZ of this enzyme were 7.5 and 30 μM, respectively. SHV-24 was found to have a D179G substitution in the Ω-loop of the enzyme.",

author = "Hiroshi Kurokawa and Tetsuya Yagi and Naohiro Shibata and Keigo Shibayama and Kazunari Kamachi and Yoshichika Arakawa",

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AU - Shibata, Naohiro

AU - Shibayama, Keigo

AU - Kamachi, Kazunari

AU - Arakawa, Yoshichika

PY - 2000

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