A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

Tamae Ohye; Hiroshi Ichinose; Toshihiro Yoshizawa; Ichiro Kanazawa; Toshiharu Nagatsu

doi:10.1016/S0304-3940(01)02210-8

A new splicing variant for human tyrosine hydroxylase in the adrenal medulla

Tamae Ohye, Hiroshi Ichinose, Toshihiro Yoshizawa, Ichiro Kanazawa, Toshiharu Nagatsu

臨床検査学科

研究成果: Article › 査読

15 被引用数 (Scopus)

抄録

It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.

本文言語	English
ページ（範囲）	157-160
ページ数	4
ジャーナル	Neuroscience Letters
巻	312
号	3
DOI	https://doi.org/10.1016/S0304-3940(01)02210-8
出版ステータス	Published - 26-10-2001

All Science Journal Classification (ASJC) codes

Neuroscience(all)

文献へのアクセス

10.1016/S0304-3940(01)02210-8

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引用スタイル

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title = "A new splicing variant for human tyrosine hydroxylase in the adrenal medulla",

abstract = "It has been reported that several mRNA isoforms of tyrosine 3-monooxygenase (tyrosine hydroxylase; TH) occur only in primates. New TH isoforms produced by skipping of exon 3 in the adrenal medulla of patients with progressive supranuclear palsy (PSP) have recently been reported, J. Neurochem. 67 (1996) 19. Here, we looked for the presence of new TH isoforms in control brains and adrenal medulla and in brains from patients with PSP. We found a novel type of TH mRNA in the adrenal medulla from one of the control subjects. The mRNA lacked exon 4, resulting in a premature stop codon at amino acid 147. This result suggests the importance of alternative splicing in the regulation of TH activity.",

author = "Tamae Ohye and Hiroshi Ichinose and Toshihiro Yoshizawa and Ichiro Kanazawa and Toshiharu Nagatsu",

note = "Funding Information: This work was supported by Health Science Grants, Research on Brain Science from the Ministry of Health and Welfare of Japan (to T.N.), and by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.N.).",

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AU - Kanazawa, Ichiro

AU - Nagatsu, Toshiharu

N1 - Funding Information: This work was supported by Health Science Grants, Research on Brain Science from the Ministry of Health and Welfare of Japan (to T.N.), and by a Grant-in-Aid for Scientific Research on Priority Areas from the Ministry of Education, Science, Sports and Culture of Japan (to T.N.).

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