A nonhuman primate model for human cerebral malaria: Rhesus-monkeys experimentally infected with plasmodium fragile

Hisashi Fujioka, Pascal Millet, Yoshimasa Maeno, Shusuke Nakazawa, Yoshihiro Ito, Russell J. Howard, William E. Collins, Masamichi Aikawa

研究成果: Article査読

49 被引用数 (Scopus)

抄録

We studied the brains of rhesus monkeys infected with the primate malaria parasite Plasmodium fragile. Electron microscopy showed that, in these animals, erythrocytes infected with P. fragile undergo sequestration and that parasitized red blood cells adhere to endothelial cells in the cerebral microvessels by means of knobs. Cerebral microvessels with sequestered parasitized red blood cells were shown by immunohistochemical analysis to possess the platelet glycoprotein CD36, thrombospondin, and intracellular adhesion molecule-1. The formation of rosettes also was observed in the cerebral microvessels. In a fashion similar to human cerebral malaria, P. fragile produced neurological symptoms in the animals. Thus, rhesus monkeys infected with P. fragile, like those monkeys infected with Plasmodium coatneyi, can be used as a primate model to study human cerebral malaria.

本文言語English
論文番号71040
ページ(範囲)371-376
ページ数6
ジャーナルExperimental Parasitology
78
4
DOI
出版ステータスPublished - 06-1994

All Science Journal Classification (ASJC) codes

  • 寄生虫科
  • 免疫学
  • 感染症

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