A novel anticancer drug delivery system -DAC-70/CDDP

Akio Sugitachi; Koki Otsuka; Kentaro Fujisawa; Tetsuya Itabashi; Yuji Akiyama; Akira Sasaki; Kenichiro Ikeda; Yasuo Yoshida; Yoshimori Takamori; Seiji Kurozumi; Takatoshi Mori; G. Wakabayashi

A novel anticancer drug delivery system -DAC-70/CDDP

Akio Sugitachi, Koki Otsuka, Kentaro Fujisawa, Tetsuya Itabashi, Yuji Akiyama, Akira Sasaki, Kenichiro Ikeda, Yasuo Yoshida, Yoshimori Takamori, Seiji Kurozumi, Takatoshi Mori, G. Wakabayashi

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

1 被引用数 (Scopus)

抄録

We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

本文言語	英語
ページ（範囲）	2159-2161
ページ数	3
ジャーナル	Gan to kagaku ryoho. Cancer & chemotherapy
巻	34
号	12
出版ステータス	出版済み - 11-2007
外部発表	はい

All Science Journal Classification (ASJC) codes

医学一般

UN SDG

この成果は、次の持続可能な開発目標に貢献しています

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title = "A novel anticancer drug delivery system -DAC-70/CDDP",

abstract = "We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.",

author = "Akio Sugitachi and Koki Otsuka and Kentaro Fujisawa and Tetsuya Itabashi and Yuji Akiyama and Akira Sasaki and Kenichiro Ikeda and Yasuo Yoshida and Yoshimori Takamori and Seiji Kurozumi and Takatoshi Mori and G. Wakabayashi",

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language = "English",

volume = "34",

pages = "2159--2161",

journal = "Gan to kagaku ryoho. Cancer & chemotherapy",

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T1 - A novel anticancer drug delivery system -DAC-70/CDDP

AU - Sugitachi, Akio

AU - Otsuka, Koki

AU - Fujisawa, Kentaro

AU - Itabashi, Tetsuya

AU - Akiyama, Yuji

AU - Sasaki, Akira

AU - Ikeda, Kenichiro

AU - Yoshida, Yasuo

AU - Takamori, Yoshimori

AU - Kurozumi, Seiji

AU - Mori, Takatoshi

AU - Wakabayashi, G.

PY - 2007/11

Y1 - 2007/11

N2 - We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

AB - We devised a muco-adhesive anticancer drug delivery system using 70% deacetylated chitin (DAC-70) and cisplatin (CDDP) and 5-fluorouracil (5-FU). The adhesive force between the system and human colonic mucosa was measured ex vivo, and a release profile of each drug was examined in vitro. Each system demonstrated a stronger muco-adhesive force at 37 degrees C than that of 25 degrees C. The CDDP-loaded system showed a sustained release of the drug while the 5-FU-loaded system exhibited an initial bursting of the agent. We presume that the release profile of CDDP and 5-FU is closely related to both degradability of the chitin and interactions between the chitin and each drug. The DAC-70/CDDP system would be clinically promising in loco-regional cancer chemotherapy.

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AN - SCOPUS:39049133963

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JO - Gan to kagaku ryoho. Cancer & chemotherapy

JF - Gan to kagaku ryoho. Cancer & chemotherapy

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ER -

A novel anticancer drug delivery system -DAC-70/CDDP

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All Science Journal Classification (ASJC) codes

UN SDG

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