TY - JOUR
T1 - A Patient with Giant Rippled-Pattern Sebaceoma in the Occipital Region
AU - Takahashi, Masayuki
AU - Arima, Masaru
AU - Iwata, Yohei
AU - Suzuki, Kayoko
AU - Mizoguchi, Yoshikazu
AU - Kuroda, Makoto
AU - Matsunaga, Kayoko
N1 - Publisher Copyright:
© 2016 The Author(s). Published by S. Karger AG, Basel.
PY - 2016
Y1 - 2016
N2 - A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis. A rippled pattern, or the single-line arrangement of tumor cells involving the stroma, was present. In addition, some tumor clusters revealed the differentiation to sebaceous glands, and these cells were positive for cytokeratin (AE1/AE3) and epithelial membrane antigen, which is consistent with the staining of sebaceous glands. On the contrary, tumor cells were negative for epithelial antigen (Ber-EP4), and Ki67 (MIB1) index was 5% or lower. Therefore, we diagnosed the tumor as rippled-pattern sebaceoma and not as basal cell carcinoma. Although this case was quite unique in its large size, immunostaining was useful for the definite diagnosis.
AB - A 72-year-old male visited a nearby hospital with a large tumor in his occipital region, which had existed since 20 years. Since malignant tumor was suspected, he was referred to our department. At the initial consultation, an elastic-hard, yellow-brown, sessile tumor, measuring 8 × 7 × 5 cm and with a flat surface, was observed in the occipital region. The tumor was resected and covered with artificial dermis. Histopathologically, the lesion was composed of basal-cell-like cells with nest formation in the dermis. A rippled pattern, or the single-line arrangement of tumor cells involving the stroma, was present. In addition, some tumor clusters revealed the differentiation to sebaceous glands, and these cells were positive for cytokeratin (AE1/AE3) and epithelial membrane antigen, which is consistent with the staining of sebaceous glands. On the contrary, tumor cells were negative for epithelial antigen (Ber-EP4), and Ki67 (MIB1) index was 5% or lower. Therefore, we diagnosed the tumor as rippled-pattern sebaceoma and not as basal cell carcinoma. Although this case was quite unique in its large size, immunostaining was useful for the definite diagnosis.
KW - Giant sebaceoma
KW - Occipital region
KW - Rippled pattern
UR - http://www.scopus.com/inward/record.url?scp=84982292366&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84982292366&partnerID=8YFLogxK
U2 - 10.1159/000445935
DO - 10.1159/000445935
M3 - Article
AN - SCOPUS:84982292366
SN - 1662-6567
VL - 8
SP - 107
EP - 111
JO - Case Reports in Dermatology
JF - Case Reports in Dermatology
IS - 2
ER -