A pediatric patient with interstitial pneumonia due to enterovirus D68

Masaaki Matsumoto, Hiroyuki Awano, Miki Ogi, Kazumi Tomioka, Ai Unzaki, Masahiro Nishiyama, Daisaku Toyoshima, Mariko Ikeda, Akihito Ishida, Hiroaki Nagase, Ichiro Morioka, Kazumoto Iijima

研究成果: Article

2 引用 (Scopus)

抄録

Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.

元の言語English
ページ(範囲)712-715
ページ数4
ジャーナルJournal of Infection and Chemotherapy
22
発行部数10
DOI
出版物ステータスPublished - 01-10-2016

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Enterovirus Infections
Enterovirus
Interstitial Lung Diseases
Pediatrics
Steroids
Pulmonary Surfactant-Associated Protein D
Pulmonary Surfactant-Associated Protein A
Respiratory Sounds
Bronchoalveolar Lavage
Artificial Respiration
Cough
Respiratory System
Intensive Care Units
Hospitalization
Neutrophils
Fever
Thorax
Carbohydrates
Lymphocytes
Antigens

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases

これを引用

Matsumoto, M., Awano, H., Ogi, M., Tomioka, K., Unzaki, A., Nishiyama, M., ... Iijima, K. (2016). A pediatric patient with interstitial pneumonia due to enterovirus D68. Journal of Infection and Chemotherapy, 22(10), 712-715. https://doi.org/10.1016/j.jiac.2016.03.009
Matsumoto, Masaaki ; Awano, Hiroyuki ; Ogi, Miki ; Tomioka, Kazumi ; Unzaki, Ai ; Nishiyama, Masahiro ; Toyoshima, Daisaku ; Ikeda, Mariko ; Ishida, Akihito ; Nagase, Hiroaki ; Morioka, Ichiro ; Iijima, Kazumoto. / A pediatric patient with interstitial pneumonia due to enterovirus D68. :: Journal of Infection and Chemotherapy. 2016 ; 巻 22, 番号 10. pp. 712-715.
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abstract = "Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.",
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Matsumoto, M, Awano, H, Ogi, M, Tomioka, K, Unzaki, A, Nishiyama, M, Toyoshima, D, Ikeda, M, Ishida, A, Nagase, H, Morioka, I & Iijima, K 2016, 'A pediatric patient with interstitial pneumonia due to enterovirus D68', Journal of Infection and Chemotherapy, 巻. 22, 番号 10, pp. 712-715. https://doi.org/10.1016/j.jiac.2016.03.009

A pediatric patient with interstitial pneumonia due to enterovirus D68. / Matsumoto, Masaaki; Awano, Hiroyuki; Ogi, Miki; Tomioka, Kazumi; Unzaki, Ai; Nishiyama, Masahiro; Toyoshima, Daisaku; Ikeda, Mariko; Ishida, Akihito; Nagase, Hiroaki; Morioka, Ichiro; Iijima, Kazumoto.

:: Journal of Infection and Chemotherapy, 巻 22, 番号 10, 01.10.2016, p. 712-715.

研究成果: Article

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T1 - A pediatric patient with interstitial pneumonia due to enterovirus D68

AU - Matsumoto, Masaaki

AU - Awano, Hiroyuki

AU - Ogi, Miki

AU - Tomioka, Kazumi

AU - Unzaki, Ai

AU - Nishiyama, Masahiro

AU - Toyoshima, Daisaku

AU - Ikeda, Mariko

AU - Ishida, Akihito

AU - Nagase, Hiroaki

AU - Morioka, Ichiro

AU - Iijima, Kazumoto

PY - 2016/10/1

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N2 - Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.

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Matsumoto M, Awano H, Ogi M, Tomioka K, Unzaki A, Nishiyama M その他. A pediatric patient with interstitial pneumonia due to enterovirus D68. Journal of Infection and Chemotherapy. 2016 10 1;22(10):712-715. https://doi.org/10.1016/j.jiac.2016.03.009