A pediatric patient with interstitial pneumonia due to enterovirus D68

Masaaki Matsumoto, Hiroyuki Awano, Miki Ogi, Kazumi Tomioka, Ai Unzaki, Masahiro Nishiyama, Daisaku Toyoshima, Mariko Taniguchi-Ikeda, Akihito Ishida, Hiroaki Nagase, Ichiro Morioka, Kazumoto Iijima

研究成果: Article査読

3 被引用数 (Scopus)


Enterovirus D68 (EV-D68) infection is associated with upper and lower respiratory tract symptoms such as fever, cough, and wheezing. Pediatric patients with EV-D68 infection easily develop more severe respiratory complications compared to patients infected with other species of enterovirus, and consequently, have a higher rate of hospitalization and admission to intensive care units. Therefore, the clinical picture of respiratory complications associated with EV-D68 infection needs to be elucidated. Here, we report a 4-year-old girl of EV-D68 infection that required artificial respiration management within 24 h from the onset of cold symptoms. The patient was diagnosed with interstitial pneumonia on the basis of chest imaging findings with patchy, funicular and frosted glassy shadows, increased blood markers of surfactant protein-A, surfactant protein-D and sialylated carbohydrate antigen KL-6, and increased neutrophils and lymphocytes in the bronchoalveolar lavage. Steroids showed a remarkable effect in her treatment. Further investigations are needed to confirm the efficacy of steroids for interstitial pneumonia due to EV-D68 infection. As rapid deterioration of respiratory status is observed in EV-D68 infection, the possibility of interstitial pneumonia may be considered.

ジャーナルJournal of Infection and Chemotherapy
出版ステータスPublished - 01-10-2016

All Science Journal Classification (ASJC) codes

  • 微生物学(医療)
  • 薬理学(医学)
  • 感染症


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