A polymorphism of microRNA 27a genome region is associated with the development of gastric mucosal atrophy in Japanese male subjects

Tomiyasu Arisawa, Tomomitsu Tahara, Tomoyuki Shibata, Mitsuo Nagasaka, Masakatsu Nakamura, Yoshio Kamiya, Hiroshi Fujita, Shin Hasegawa, Tamaki Takagi, Fang Yu Wang, Ichiro Hirata, Hiroshi Nakano

研究成果: Article査読

38 被引用数 (Scopus)

抄録

Noncoding microRNAs regulate the expression of various mRNAs. We attempted to clarify the relationship between miR-27a genome polymorphism and chronic gastritis. The study was performed in 179 patients with no evidence of gastric malignancy. The severity of histologic chronic gastritis was classified according to the updated Sydney system. The frequency of miR-27a G allele was 34.6%. Although the frequencies of miR-27a G allele were increased in subjects with peptic ulcer or severe mucosal atrophy, no significant differences were seen. The miR-27a polymorphism showed an interaction with gender in relation to gastric mucosal atrophy (P=.090). In only male subjects, the miR-27a polymorphism was associated with the gastric mucosal atrophy (P=.039) and both atrophy and metaplasia scores in G/G group were significantly higher than those in the other groups. The miR-27a genome region polymorphism may be an important definitive factor to develop the gastric mucosal atrophy in Japanese male subjects.

本文言語English
ページ(範囲)1691-1697
ページ数7
ジャーナルDigestive Diseases and Sciences
52
7
DOI
出版ステータスPublished - 07-2007

All Science Journal Classification (ASJC) codes

  • 生理学
  • 消化器病学

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