A possible role of protein kinase C in signal-induced lysosomal enzyme release

Norio Kajikawa, Kozo Kaibuchi, Tsukasa Matsubara, Ushio Kikkawa, Yoshimi Takai, Yasutomi Nishizuka, Kiyoshi Itoh, Chikanori Tomioka

研究成果: ジャーナルへの寄稿学術論文査読

79 被引用数 (Scopus)

抄録

In platelets, activation of protein kinase C and mobilization of Ca2+ were selectively induced by the addition of 1-oleoyl-2-acetyl-glycerol and a low concentration of A23187, respectively (Kaibuchi, K., Takai, Y., Sawamura, M., Hoshijima, M., Fujikura, T. and Nishizuka, Y. (1983) J. Biol. Chem. 258, 6701-6704). Using this procedure evidence was obtained suggesting that the protein phosphorylation and Ca2+ mobilization were both essential and synergistically effective to cause release of lysosomal acid hydrolases such as N-acetylglucosaminidase. A similar observation was made for the lysosomal enzyme release from rat neutrophils.

本文言語英語
ページ(範囲)743-750
ページ数8
ジャーナルBiochemical and Biophysical Research Communications
116
2
DOI
出版ステータス出版済み - 31-10-1983
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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