A preliminary examination of the association between locomotive syndrome and circulating miRNA-199 in community-dwelling people: The Yakumo study

Yasuhiko Takegami, Taisuke Seki, Yusuke Osawa, Kazuya Makida, Satoshi Ochiai, Hiroaki Nakashima, Ryosuke Fujii, Hiroya Yamada, Koji Suzuki, Yukiharu Hasegawa, Shiro Imagama

研究成果: Article査読

抄録

Background: The risk of locomotive syndrome (LS) has been proposed as a criterion for evaluating physical ability. The expression levels of circulating miRNAs (c-miRNAs) are predictors of various diseases. This preliminary study aimed to evaluate the relationship between serum levels of several miRNAs and LS. Methods: We enrolled 423 participants in whom we conducted a survey with the 25-question Geriatric Locomotive Function Scale (GLFS-25) and measured the serum levels of 21 c-miRNAs. The relationship between the GLFS-25 and each c-miRNA was evaluated with a linear regression analysis, and independent associations between the GLFS-25 and each c-miRNA were assessed with a multiple regression analysis using various independent variables. Results: Only the serum level of miR-199 was significantly associated with LS after adjustment for age, BMI, sex, and all comorbidities. The receiver operating characteristics curve for the predictive value of the miR-199 level to indicate the presence or absence of LS risk had an area under the curve (AUC) of 0.576 (95% confidence interval: 0.501–0.651). Conclusion: The expression level of miRNA-199 was associated with the risk of LS in community-dwelling Japanese people.

本文言語English
ジャーナルJournal of Orthopaedic Science
DOI
出版ステータスAccepted/In press - 2021

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

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