A prospective study of intensity-modified radiation therapy in comparison with conventional 3D-RT for BR pancreatic cancer patients with arterial involvement

Toshihiko Masui, Kyoichi Takaori, Takayuki Anazawa, Asahi Sato, Kenzo Nakano, Yuichiro Uchida, Akitada Yogo, Yoko Goto, Shigemi Matsumoto, Yuzo Kodama, Masashi Kanai, Hiroyoshi Isoda, Masaki Mizumoto, Yoshiya Kawaguchi, Keiko Shibuya, Satoshi Itasaka, Shinji Uemoto

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Background/Aim: Intensity-modulated radiation therapy (IMRT) is a form of radiation therapy that allows accurate irradiation with reduced damage to surrounding tissues. Here, we analyzed borderline-resectable pancreatic cancer (BRPC) with arterial abutment (BR-A) patients with IMRT as neoadjuvant therapy and performed comparisons with patients with conventional RT to clarify the advantages of IMRT as a neoadjuvant therapy. Patients and Methods: Thirty BR-A patients treated at our hospital between January 2012 and December 2015 were divided into two groups: 12 patients underwent conventional 3D-RT before resection (RT group); and 18 patients underwent IMRT before resection (IMRT group). We analyzed safety, tumor resection rate, histological classification of the tumor and overall survival. Results: The R0 rate was 84% for the IMRT group and 83% for the RT group. Local therapeutic effects as assessed by Evans classification showed a higher local control rate in the IMRT group (Grade: 1, 0%; 2a, 25%; 2b, 41.6%; 3, 17%; 4, 8%) than in the RT group (Grade: 1, 17%; 2a, 50%; 2b, 17%; 3, 17%; 4, 0%). The cumulative dose of S1 treatment as adjuvant therapy was much smaller in the RT group (18.3%) compared to that in the IMRT group (57.1%, p=0.047), and with better subsequent overall survival rate (MST 32 months vs. 13.8 months, p=0.0273). Conclusion: The IMRT group showed a better control rate than the RT group. The neoadjuvant IMRT has advantages of higher completion rate of adjuvant chemotherapy with better nutritional status and better subsequent overall survival rate (OS).

本文言語English
ページ(範囲)7023-7030
ページ数8
ジャーナルAnticancer research
37
12
DOI
出版ステータスPublished - 2017
外部発表はい

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究

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