A report of ceftazidime-resistant klebsiella pneumoniae

The minimum inhibitory concentrations (MIC) of ceftazidime (CAZ), piperacillin (PIPC), sulbenicillin (SBPC), ceftizoxime (CZX), ceftriaxone (CTRX), cefpirome (CPR), latamoxef (LMOX) and cefminox (CMNX) were determined for eight strains of CAZ-resistant Klebsiella pneumoniae isolated from clinical samples collected in Japan between July and September 1994. MICs were measured by the broth microdilution method as described by the Japan Society of Chemotherapy. MICs of over 400 μg/ml were obtained with CAZ in two of the eight strains. The implications of these and other results obtained on the eight CAZ-resistant Klebsiella pneumoniae strains in the present study are discussed.