A selective phosphodiesterase IV inhibitor, rolipram blocks both withdrawal behavioral manifestations, and c-Fos protein expression in morphine dependent mice

Moustafa Mahmoud Hamdy, Takayoshi Mamiya, Yukihiro Noda, Merfat Sayed, Abdel Azim Assi, Adel Gomaa, Kiyofumi Yamada, Toshitaka Nabeshima

研究成果: Article査読

28 被引用数 (Scopus)

抄録

We investigated the effect of rolipram, a selective phosphodiesterase IV inhibitor, on morphine dependence in mice. The withdrawal manifestations were significantly reduced in mice that were treated with rolipram in combination with morphine repeatedly, compared to the mice treated with morphine and saline. Immunohistochemical study of c-Fos protein revealed a significant increase in the protein expression, 1 h after naloxone induced withdrawal manifestations. A combination of rolipram and morphine treatment for 5 days prevented the increase of c-Fos protein expression. Acute rolipram treatment prior to the naloxone challenge had no effect. Repeated treatment with rolipram itself had no effect either on behavior, or on c-Fos protein expression. These results suggest that chronic rolipram treatment in combination with morphine in mice will abolish the development of morphine dependence and the expression of c-Fos protein induced by naloxone challenge.

本文言語English
ページ(範囲)85-93
ページ数9
ジャーナルBehavioural Brain Research
118
1
DOI
出版ステータスPublished - 08-01-2001

All Science Journal Classification (ASJC) codes

  • 行動神経科学

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