A simple proteinuria-based risk score predicts contrast-associated acute kidney injury after percutaneous coronary intervention

Wakaya Fujiwara, Hideki Ishii, Yoshihiro Sobue, Shinya Shimizu, Tomoya Ishiguro, Ryo Yamada, Sayano Ueda, Hideto Nishimura, Yudai Niwa, Akane Miyazaki, Wataru Miyagi, Shuhei Takahara, Hiroyuki Naruse, Junichi Ishii, Ken Kiyono, Eiichi Watanabe, Hideo Izawa

研究成果: Article査読

抄録

Contrast-associated acute kidney injury (CA-AKI) is a complication of percutaneous coronary intervention (PCI). Because proteinuria is a sentinel marker of renal dysfunction, we assessed its role in predicting CA-AKI in patients undergoing PCI. A total of 1,254 patients undergoing PCI were randomly assigned to a derivation (n = 840) and validation (n = 414) dataset. We identified the independent predictors of CA-AKI where CA-AKI was defined by the new criteria issued in 2020, by a multivariate logistic regression in the derivation dataset. We created a risk score from the remaining predictors. The discrimination and calibration of the risk score in the validation dataset were assessed by the area under the receiver-operating characteristic curves (AUC) and Hosmer–Lemeshow test, respectively. A total of 64 (5.1%) patients developed CA-AKI. The 3 variables of the risk score were emergency procedures, serum creatinine, and proteinuria, which were assigned 1 point each based on the correlation coefficient. The risk score demonstrated a good discriminative power (AUC 0.789, 95% CI 0.766–0.912) and significant calibration. It was strongly associated with the onset of CA-AKI (Cochran-Armitage test, p < 0.0001). Our risk score that included proteinuria was simple to obtain and calculate, and may be useful in assessing the CA-AKI risk before PCI.

本文言語English
論文番号12331
ジャーナルScientific reports
12
1
DOI
出版ステータスPublished - 12-2022

All Science Journal Classification (ASJC) codes

  • 一般

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