A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B

T. Murata; F. Goshima; T. Koshizuka; H. Takakuwa; Y. Nishiyama

doi:10.1128/JVI.75.2.1039-1043.2001

A single amino acid substitution in the ICP27 protein of herpes simplex virus type 1 is responsible for its resistance to leptomycin B

T. Murata
, F. Goshima
, T. Koshizuka
, H. Takakuwa
, Y. Nishiyama

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

22 被引用数 (Scopus)

抄録

Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.

本文言語	英語
ページ（範囲）	1039-1043
ページ数	5
ジャーナル	Journal of Virology
巻	75
号	2
DOI	https://doi.org/10.1128/JVI.75.2.1039-1043.2001
出版ステータス	出版済み - 2001
外部発表	はい

All Science Journal Classification (ASJC) codes

微生物学
免疫学
昆虫科学
ウイルス学

文献へのアクセス

10.1128/JVI.75.2.1039-1043.2001

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引用スタイル

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abstract = "Leptomycin B (LMB) is a specific inhibitor of Crm1-dependent nuclear export of proteins. The replication of herpes simplex virus (HSV) is normally highly sensitive to LMB; a resistant HSV variant, however, was isolated by serial passages of the virus. Analysis of marker transfer and viral DNA sequences revealed that a single amino acid substitution within the ICP27 gene is responsible for conferring this resistance.",

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AU - Takakuwa, H.

AU - Nishiyama, Y.

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