A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

Yoshifumi Takei, Kenji Kadomatsu, Yukio Yuzawa, Seiichi Matsuo, Takashi Muramatsu

研究成果: Article

345 引用 (Scopus)

抜粋

Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer cell line, PC-3, whereas the control scramble siRNA showed no effects. The VEGF siRNA with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.

元の言語English
ページ(範囲)3365-3370
ページ数6
ジャーナルCancer Research
64
発行部数10
DOI
出版物ステータスPublished - 15-05-2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

フィンガープリント A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用