A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics

Yoshifumi Takei, Kenji Kadomatsu, Yukio Yuzawa, Seiichi Matsuo, Takashi Muramatsu

研究成果: Article

342 引用 (Scopus)

抄録

Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer cell line, PC-3, whereas the control scramble siRNA showed no effects. The VEGF siRNA with atelocollagen dramatically suppressed tumor angiogenesis and tumor growth in a PC-3 s.c. xenograft model. Atelocollagen provided a beneficial delivering means by which stabilization and efficient transfection of the siRNA injected into the tumors were achieved.

元の言語English
ページ(範囲)3365-3370
ページ数6
ジャーナルCancer Research
64
発行部数10
DOI
出版物ステータスPublished - 15-05-2004
外部発表Yes

Fingerprint

Vascular Endothelial Growth Factor A
Small Interfering RNA
Neoplasms
Pathologic Neovascularization
Therapeutics
RNA Interference
Heterografts
Transfection
Prostatic Neoplasms
Cell Line
Growth
atelocollagen

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

これを引用

Takei, Yoshifumi ; Kadomatsu, Kenji ; Yuzawa, Yukio ; Matsuo, Seiichi ; Muramatsu, Takashi. / A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. :: Cancer Research. 2004 ; 巻 64, 番号 10. pp. 3365-3370.
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A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. / Takei, Yoshifumi; Kadomatsu, Kenji; Yuzawa, Yukio; Matsuo, Seiichi; Muramatsu, Takashi.

:: Cancer Research, 巻 64, 番号 10, 15.05.2004, p. 3365-3370.

研究成果: Article

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