A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects

Takayoshi Koide, Branko Aleksic, Yoshihito Ito, Hinako Usui, Akira Yoshimi, Toshiya Inada, Michio Suzuki, Ryota Hashimoto, Masatoshi Takeda, Nakao Iwata, Norio Ozaki

研究成果: Article査読

16 被引用数 (Scopus)

抄録

We examined the association of schizophrenia (SCZ) and dihydropyrimidinase- like 2 (DPYSL2), also known as collapsin response mediator protein 2, which regulates axonal growth and branching. We genotyped 20 tag single nucleotide polymorphisms (SNPs) in 1464 patients and 1310 controls. There were two potential associations in a screening population of 384 patients and 384 controls (rs2585458: P=0.046, rs4733048: P=0.014). However, we could not replicate these associations in a confirmatory population of 1080 patients and 926 controls (rs2585458: P=0.39, rs4733048: P=0.70) or a joint analysis (rs2585458: P=0.72, rs4733048: P=0.10). We conclude that DPYSL2 does not have a major function in SCZ in Japanese subjects.

本文言語English
ページ(範囲)469-472
ページ数4
ジャーナルJournal of Human Genetics
55
7
DOI
出版ステータスPublished - 07-2010

All Science Journal Classification (ASJC) codes

  • Genetics
  • Genetics(clinical)

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