ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

Akiyoshi Nakayama; Hirotaka Matsuo; Tappei Takada; Kimiyoshi Ichida; Takahiro Nakamura; Yuki Ikebuchi; Kousei Ito; Tatsuo Hosoya; Yoshikatsu Kanai; Hiroshi Suzuki; Nariyoshi Shinomiya

doi:10.1080/15257770.2011.633953

ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

Akiyoshi Nakayama
, Hirotaka Matsuo
, Tappei Takada
, Kimiyoshi Ichida
, Takahiro Nakamura
, Yuki Ikebuchi
, Kousei Ito
, Tatsuo Hosoya
, Yoshikatsu Kanai
, Hiroshi Suzuki
, Nariyoshi Shinomiya

研究成果: ジャーナルへの寄稿 › 学術論文 › 査読

73 被引用数 (Scopus)

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The ATP-binding cassette, subfamily G, member 2 (ABCG2/BCRP) gene encodes a well-known transporter, which exports various substrates including nucleotide analogs such as 3'-azido-3' - deoxythymidine (AZT). ABCG2 is also located in a gout-susceptibility locus (MIM 138900) on chromosome 4q, and has recently been identified by genome-wide association studies to relate to serum uric acid (SUA) and gout. Becuase urate is structurally similar to nucleotide analogs, we hypothesized that ABCG2 might be a urate exporter. To demonstrate our hypothesis, transport assays were performed with membrane vesicles prepared from ABCG2-overexpressing cells. Transport of

本文言語	英語
ページ（範囲）	1091-1097
ページ数	7
ジャーナル	Nucleosides, Nucleotides and Nucleic Acids
巻	30
号	12
DOI	https://doi.org/10.1080/15257770.2011.633953
出版ステータス	出版済み - 2011
外部発表	はい

All Science Journal Classification (ASJC) codes

生化学
分子医療
遺伝学

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10.1080/15257770.2011.633953

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AU - Ichida, Kimiyoshi

AU - Nakamura, Takahiro

AU - Ikebuchi, Yuki

AU - Ito, Kousei

AU - Hosoya, Tatsuo

AU - Kanai, Yoshikatsu

AU - Suzuki, Hiroshi

AU - Shinomiya, Nariyoshi

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ABCG2 is a high-capacity urate transporter and its genetic impairment increases serum uric acid levels in humans

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