Aberrant DNA replication in cancer

Motoshi Suzuki, Takashi Takahashi

研究成果: Review article

12 引用 (Scopus)

抜粋

Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.

元の言語English
ページ(範囲)111-117
ページ数7
ジャーナルMutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
743-744
DOI
出版物ステータスPublished - 01-03-2013

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Health, Toxicology and Mutagenesis

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