TY - JOUR
T1 - Aberrant DNA replication in cancer
AU - Suzuki, Motoshi
AU - Takahashi, Takashi
N1 - Funding Information:
We thank Drs. Adonis Skandalis at Brock University and Yuji Masuda at Nagoya University for critical reading of this manuscript. This work was supported in part by a Grant-in-Aid for Scientific Research on Innovative Areas from the Ministry of Education, Culture, Sports, Science, and Technology of Japan , and a Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science .
PY - 2013/3
Y1 - 2013/3
N2 - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.
AB - Genomic instability plays an important role in cancer susceptibility, though the mechanics of its development remain unclear. An often-stated hypothesis is that error-prone phenotypes in DNA replication or aberrations in translesion DNA synthesis lead to genomic instability and cancer. Mutations in core DNA replication proteins have been identified in human cancer, although DNA replication is essential for cell proliferation and most mutations eliminating this function are deleterious. With recent developments in this field we review and discuss the possible involvement of DNA replication proteins in carcinogenesis.
UR - https://www.scopus.com/pages/publications/84877924200
UR - https://www.scopus.com/pages/publications/84877924200#tab=citedBy
U2 - 10.1016/j.mrfmmm.2012.07.003
DO - 10.1016/j.mrfmmm.2012.07.003
M3 - Review article
C2 - 22968031
AN - SCOPUS:84877924200
SN - 0027-5107
VL - 743-744
SP - 111
EP - 117
JO - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
JF - Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
ER -
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