Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice

Yuji Kitaichi, Ryota Hashimoto, Takeshi Inoue, Tomohiro Abekawa, Aya Kakuta, Satoko Takai, Tsukasa Koyama

研究成果: Article

抄録

Objective Glycine regulates glutamatergic neurotransmission, and several papers have reported the relationship between glycine and schizophrenia. The dysbindin-1 (DTNBP1: dystrobrevin-binding protein 1) gene is related to glutamatergic neurotransmission and has been found to be a strong candidate gene for schizophrenia. In this study, we clarified the relationship between dysbindin, glutamate, and glycine with in vivo microdialysis methods. Methods We measured extracellular glycine and glutamate levels in the striatum of sandy (sdy) mice using in vivo microdialysis methods. Sdy mice express no dysbindin protein owing to a deletion in the dysbindin-1 gene. In addition, we measured changes in those amino acids after methamphetamine (METH) administration. Results The basal levels of extracellular glycine and glutamate in the striatum of sdy mice were elevated. These extracellular glutamate levels decreased gradually after METH administration and were not subsequently different from those of wild-type mice. Conclusions These results suggest that dysbindin might modulate glycine and glutamate release in vivo.

元の言語English
ページ(範囲)215-220
ページ数6
ジャーナルActa Neuropsychiatrica
25
発行部数4
DOI
出版物ステータスPublished - 01-01-2013
外部発表Yes

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Glycine
Glutamic Acid
Methamphetamine
Microdialysis
Synaptic Transmission
Schizophrenia
Carrier Proteins
Genes
Amino Acids
Proteins
dystrobrevin

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

これを引用

Kitaichi, Y., Hashimoto, R., Inoue, T., Abekawa, T., Kakuta, A., Takai, S., & Koyama, T. (2013). Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. Acta Neuropsychiatrica, 25(4), 215-220. https://doi.org/10.1111/acn.12018
Kitaichi, Yuji ; Hashimoto, Ryota ; Inoue, Takeshi ; Abekawa, Tomohiro ; Kakuta, Aya ; Takai, Satoko ; Koyama, Tsukasa. / Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. :: Acta Neuropsychiatrica. 2013 ; 巻 25, 番号 4. pp. 215-220.
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Kitaichi, Y, Hashimoto, R, Inoue, T, Abekawa, T, Kakuta, A, Takai, S & Koyama, T 2013, 'Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice', Acta Neuropsychiatrica, 巻. 25, 番号 4, pp. 215-220. https://doi.org/10.1111/acn.12018

Abnormalities in extracellular glycine and glutamate levels in the striatum of sandy mice. / Kitaichi, Yuji; Hashimoto, Ryota; Inoue, Takeshi; Abekawa, Tomohiro; Kakuta, Aya; Takai, Satoko; Koyama, Tsukasa.

:: Acta Neuropsychiatrica, 巻 25, 番号 4, 01.01.2013, p. 215-220.

研究成果: Article

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AU - Kakuta, Aya

AU - Takai, Satoko

AU - Koyama, Tsukasa

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N2 - Objective Glycine regulates glutamatergic neurotransmission, and several papers have reported the relationship between glycine and schizophrenia. The dysbindin-1 (DTNBP1: dystrobrevin-binding protein 1) gene is related to glutamatergic neurotransmission and has been found to be a strong candidate gene for schizophrenia. In this study, we clarified the relationship between dysbindin, glutamate, and glycine with in vivo microdialysis methods. Methods We measured extracellular glycine and glutamate levels in the striatum of sandy (sdy) mice using in vivo microdialysis methods. Sdy mice express no dysbindin protein owing to a deletion in the dysbindin-1 gene. In addition, we measured changes in those amino acids after methamphetamine (METH) administration. Results The basal levels of extracellular glycine and glutamate in the striatum of sdy mice were elevated. These extracellular glutamate levels decreased gradually after METH administration and were not subsequently different from those of wild-type mice. Conclusions These results suggest that dysbindin might modulate glycine and glutamate release in vivo.

AB - Objective Glycine regulates glutamatergic neurotransmission, and several papers have reported the relationship between glycine and schizophrenia. The dysbindin-1 (DTNBP1: dystrobrevin-binding protein 1) gene is related to glutamatergic neurotransmission and has been found to be a strong candidate gene for schizophrenia. In this study, we clarified the relationship between dysbindin, glutamate, and glycine with in vivo microdialysis methods. Methods We measured extracellular glycine and glutamate levels in the striatum of sandy (sdy) mice using in vivo microdialysis methods. Sdy mice express no dysbindin protein owing to a deletion in the dysbindin-1 gene. In addition, we measured changes in those amino acids after methamphetamine (METH) administration. Results The basal levels of extracellular glycine and glutamate in the striatum of sdy mice were elevated. These extracellular glutamate levels decreased gradually after METH administration and were not subsequently different from those of wild-type mice. Conclusions These results suggest that dysbindin might modulate glycine and glutamate release in vivo.

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