Abnormalities of sensory and memory functions in mice lacking Bsg gene

Kazumasa Naruhashi, Kenji Kadomatsu, Tadahiko Igakura, Qi Wen Fan, Naohiko Kuno, Hisako Muramatsu, Teruo Miyauchi, Takaaki Hasegawa, Akio Itoh, Takashi Muramatsu, Toshitaka Nabeshima

研究成果: Article査読

80 被引用数 (Scopus)


Basigin is a highly glycosylated transmembrane protein belonging to the immunoglobulin superfamily. We used mutant mice lacking the basigin gene (Bsg) to investigate its involvement in learning and memory. Mutations were generated by the gene targeting method. Various kinds of learning and memory tasks were performed in mutant, hetero and wild type mice. The mutant mice showed worse performance than the wild and hetero mice in the Y-maze task, which assesses short-term memory, and in the water finding task, which examines latent learning, without any motor dysfunction. Moreover, the mutant mice showed less acclimation in the habituation task compared with the wild-type mice. The mutant mice were also more sensitive to electric foot-shock. These findings are consistent with the expression profile of basigin in the central nervous system. Thus, basigin may play an important role in learning and memory as well as in the sensory functions.

ジャーナルBiochemical and Biophysical Research Communications
出版ステータスPublished - 30-07-1997

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学


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