Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: A diffusion tensor tractography study

Kuniaki Kiuchi, Masayuki Morikawa, Toshiaki Taoka, Tomohisa Nagashima, Takahira Yamauchi, Manabu Makinodan, Kazunobu Norimoto, Kazumichi Hashimoto, Jun Kosaka, Yuichiro Inoue, Makoto Inoue, Kimihiko Kichikawa, Toshifumi Kishimoto

研究成果: ジャーナルへの寄稿学術論文査読

104 被引用数 (Scopus)

抄録

Mild cognitive impairment (MCI) is considered the transitional stage between normal cognition and dementia. The aim of this study was to use tractography based analysis to elucidate alterations in subjects with MCI compared with subjects with early Alzheimer's disease (AD) and controls. Seventeen subjects with early AD, 16 with MCI and 16 controls underwent magnetic resonance diffusion tensor imaging (DTI) and neuropsychological assessment. Diffusion tensor tractographies were computed and fiber-tract maps were generated using "dTV II" DTI software. We measured mean fractional anisotropy (FA) and apparent diffusion coefficient (ADC) values along the uncinate fasciculus (UNC), posterior cingulate fasciculus (PCF) and corticospinal tract (CST). There were statistically significant differences in the FA and ADC values of the UNC and PCF between subjects with early AD and controls. Subjects with MCI exhibited significantly lower FA values on both sides of the PCF relative to controls. However, there were no significant differences between subjects with early AD and MCI for any measurement. Our results suggest that alterations in the PCF precede the onset of dementia.

本文言語英語
ページ(範囲)184-191
ページ数8
ジャーナルBrain Research
1287
DOI
出版ステータス出版済み - 01-09-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学一般
  • 分子生物学
  • 臨床神経学
  • 発生生物学

フィンガープリント

「Abnormalities of the uncinate fasciculus and posterior cingulate fasciculus in mild cognitive impairment and early Alzheimer's disease: A diffusion tensor tractography study」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル