Absence of common polymorphisms of toll like receptor 4 (TLR4): Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan

Tomomitsu Tahara, Tomiyasu Arisawa, Tomoyuki Shibata, Ichiro Hirata, Hiroshi Nakano

研究成果: Article

26 引用 (Scopus)

抄録

Host genetic factors may play a key role in determining the long-term outcome of the Helicobacter pylori (H. pylori) infection. Toll-like receptor 4 (TLR4) mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of gram-negative bacterial infections. The aim of this study is to investigate the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japanese population. The study was performed in 149 gastric cancer (GC) cases (mean age 64.0 ± 12.4, M:F = 109:40) and 94 patients without evidence of GC (mean age 64.1 ± 12.3, M:F = 65:25) as the control group. TLR4 Asp299Gly, Thr399Ile were determined by Polymerase chain reaction-length of polymorphisms (PCR-RFLP) in all the patients. Asp299Gly, Thr399Ile were not detected in all 243 patients enrolled in this study. In conclusion, our data suggest that TLR4 Asp299Gly, Thr399Ile are very rare in Japanese population and thus they may not be a important factor in determining the outcome of H. pylori infected individuals in Japan.

元の言語English
ページ(範囲)62-65
ページ数4
ジャーナルJournal of Clinical Biochemistry and Nutrition
40
発行部数1
DOI
出版物ステータスPublished - 01-01-2007

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Toll-Like Receptor 4
Polymorphism
Japan
Helicobacter pylori
Stomach Neoplasms
Gram-Negative Bacterial Infections
Polymerase Chain Reaction
Polymerase chain reaction
Helicobacter Infections
Restriction Fragment Length Polymorphisms
Population
Polysaccharides
Control Groups

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Clinical Biochemistry

これを引用

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title = "Absence of common polymorphisms of toll like receptor 4 (TLR4): Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan",
abstract = "Host genetic factors may play a key role in determining the long-term outcome of the Helicobacter pylori (H. pylori) infection. Toll-like receptor 4 (TLR4) mediated recognition of lipo-polysaccharide (LPS) is required for efficient recognition of gram-negative bacterial infections. The aim of this study is to investigate the effects of common polymorphisms of TLR4 Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japanese population. The study was performed in 149 gastric cancer (GC) cases (mean age 64.0 ± 12.4, M:F = 109:40) and 94 patients without evidence of GC (mean age 64.1 ± 12.3, M:F = 65:25) as the control group. TLR4 Asp299Gly, Thr399Ile were determined by Polymerase chain reaction-length of polymorphisms (PCR-RFLP) in all the patients. Asp299Gly, Thr399Ile were not detected in all 243 patients enrolled in this study. In conclusion, our data suggest that TLR4 Asp299Gly, Thr399Ile are very rare in Japanese population and thus they may not be a important factor in determining the outcome of H. pylori infected individuals in Japan.",
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Absence of common polymorphisms of toll like receptor 4 (TLR4) : Asp299Gly, Thr399Ile in patients with gastroduodenal diseases in Japan. / Tahara, Tomomitsu; Arisawa, Tomiyasu; Shibata, Tomoyuki; Hirata, Ichiro; Nakano, Hiroshi.

:: Journal of Clinical Biochemistry and Nutrition, 巻 40, 番号 1, 01.01.2007, p. 62-65.

研究成果: Article

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