Accelerated apoptosis of peripheral blood monocytes in Cebpb-deficient mice

Akihiro Tamura, Hideyo Hirai, Asumi Yokota, Atsushi Sato, Tsukimi Shoji, Takahiro Kashiwagi, Masaki Iwasa, Aya Fujishiro, Yasuo Miura, Taira Maekawa

研究成果: ジャーナルへの寄稿学術論文査読

20 被引用数 (Scopus)

抄録

The CCAAT/enhancer-binding protein β (C/EBPβ) transcription factor is required for granulopoiesis under stress conditions. However, little is known about its roles in steady state hematopoiesis. Here, we analyzed the peripheral blood and bone marrow of Cebpb-/- mice at steady state by flow cytometry and unexpectedly found that the number of peripheral blood monocytes was severely reduced, while the number of bone marrow monocytes was maintained. The ability of Cebpb-/- bone marrow cells to give rise to macrophages/monocytes in vitro was comparable to that of wild-type bone marrow cells. Apoptosis of monocytes was enhanced in the peripheral blood, but not in the bone marrow of Cebpb-/- mice. These results indicate that C/EBPβ is required for the survival of monocytes in peripheral blood.

本文言語英語
ページ(範囲)654-658
ページ数5
ジャーナルBiochemical and Biophysical Research Communications
464
2
DOI
出版ステータス出版済み - 30-07-2015
外部発表はい

All Science Journal Classification (ASJC) codes

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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