Action potential characteristics in the sinus venosa of patients with and without atrial flutter

Masahide Harada, Toshiyuki Osaka, Eriko Yokoyama, Yoshio Takemoto, Atsushi Ito, Itsuo Kodama

研究成果: Article査読

3 被引用数 (Scopus)

抄録

Background: A functional line of conduction block is often observed in the sinus venosa (SV) during typical atrial flutter (AFL). Little information, however, is available as to the action potential characteristics in the SV with respect to the functional block. Methods and Results: Monophasic action potentials (MAPs) from the SV and lateral wall of the right atrium were recorded in 7 patients with paroxysmal AFL and 11 control patients. For both the control and AFL patients, the MAP duration at 90% repolarization (MAPD90) in the SV was longer, and the MAPD90 restitution slope was less steep than in the lateral wall. The MAPD90 in the SV in the AFL patients was slightly longer than that in the controls at the shortest cycle length (CL) tested (300 ms). However, the MAPD90s at longer CLs (350-700 ms), as well as the MAPD90 restitution slopes in the SV were comparable between the 2 groups. Conclusions: The MAPs in the SV are characterized by a long duration and flat restitution kinetics in humans. MAP properties to facilitate the development of conduction block in the SV are not appreciable in patients with paroxysmal typical AFL.

本文言語English
ページ(範囲)647-653
ページ数7
ジャーナルCirculation Journal
73
4
DOI
出版ステータスPublished - 04-2009
外部発表はい

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

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